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Calculation of sample size The G*Power software (version 3.1.9.7) was used to determine the sample size, predicated upon an expected moderate-effect size ( f = 0.25) for detecting intergroup differences in the primary outcome (DAS28-CRP)

By supporting sustained weight loss, Semaglutide helps reduce the inflammation and hormone-related risks associated with obesity

This combined therapy demonstrated superior effectiveness in lowering HbA1c and reducing cardiovascular risks compared to monotherapy, with additional benefits such as reduced body weight and lower blood pressure, both crucial factors in managing Type 2 diabetes

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Measurable weight loss typically begins during weeks two through four as your reduced calorie intake compounds