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On social media, people cite all kinds of reasons for microdosing GLP-1s: wanting to lose just a few pounds, quieting food noise, reducing cravings for alcohol or other substances or even pursuing longevity benefits
Most prominently, studies on RTD caused by SLC52A2/SLC52A3 mutations show that systemic delivery of AAV9-SLC52A2 in loss-of-function mouse models restores transporter expression, corrects spinal motor neuron energy deficits, reverses motor dysfunction, and extends survival
Repeat labs (A1c, lipids, kidney, liver) to track metabolic improvements, not just weight
That means looking at the whole picture, not just the highlights
Histamine intolerance can be linked to MTHFR gene mutations and methylation issues
doi: 10.4995/wrs.2015.3644 165
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