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In trials to assess semaglutides effectiveness for reducing the risk of major cardiovascular events in adults, increases in total bilirubin greater than or equal to 3 times the upper limit of normal were seen in .3% of people taking Wegovy versus .2% of people taking the placebo

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Martin Hamburger filed a proposed class action against the insurer and pharmacy benefit manager in September 2025 in the US District Court for the District of Columbia, alleging the exclusion amounted to an illegal denial of benefits and breach of fiduciary duty under ERISA

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