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FOXO4-DRI Safety and Side Effects: What the Evidence Shows (2026) In the published mouse studies, FOXO4-DRI caused no reported side effects: treated animals kept their weight, blood counts, and organ markers while senescent cells were cleared, and the peptide spared healthy cells in culture

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Both metalloproteinase and plasmin play a role in matrix remodeling and the renewal of ECM

Full and uncropped western blots are uploaded as the original data