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Functionally it is a straightforward GHRH-receptor agonist: it binds the receptor on pituitary somatotrophs and stimulates endogenous, pulsatile GH release, which secondarily raises IGF-1

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As a member of TGF- superfamily, BMP4 promotes epithelial-mesenchymal transition (EMT) via the canonical Smad signaling pathway, thereby driving tumor cell metastasis and invasion

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