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MMP9 secretion increases BBB permeability [46]

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Furthermore, polymorphisms in the BDNF antisense (BDNF-AS) genespecifically rs925946, rs1519480, and rs10767658show significant associations with chronic tinnitus, with rs10767658 conferring a 2.33-fold increased risk in the recessive model and demonstrating associations with tinnitus duration (Yuksel et al., 2023)

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