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In transfected cells 79 and mammals 66 , BPA has a higher affinity for GPER than either ER or ER, and BPA binding to GPER activates Akt and ERK pathways 79 , consistent with changes we observed

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Notably, the MSNs-ss-SA treatment induced the most significant increase in both SA and JA contents, with a 99.06% increase in SA and a 213.85% increase in JA compared with that of control group

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Although current recommendations for Se therapy extend only to GO patients, Se supplementation has been widely used by clinicians for a variety of other thyroid disorders