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Dave BP, Chorawala MR, Shah IV, et al

Some of this data now that I'm talking about is in diabetes, but some of it's not

Living With Permanent Vision Loss From NAION Patients who develop NAION face lifelong consequences that no medical intervention can reverse, as current science offers no effective treatment once optic nerve tissue has died

Since HNMT (the intracellular histamine-degrading enzyme) requires SAMe, impaired methylation can slow histamine clearance, especially in tissues like the brain and airways, where HNMT is the primary clearance pathway

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doi: 10.1016/S2213-8587(18)30104-9 65 Van Der Aart-Van Der BeekA