LY3463251 is the first GDF-15 agonist that has completed a phase 1 clinical trial WL was 3% after a 12-week treatment period [100]
* Correspondence: Xun Wu, [email protected] These authors have contributed equally to this work ORCID: Tanwei Fang, orcid.org/0009-0006-0404-7553 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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These early indicators validate the compounds dual mechanism, which leverages GLP-1 for appetite suppression and glucagon to accelerate energy expenditure and fat reduction in the liver, positioning DA-1726 as a potent contender in the metabolic therapeutic landscape
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