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Samples were centrifuged (13,000 rpm, 1 min, Biofuge Pico, Heraeus, Thermo Fisher Scientific, USA) and the fluorescent signal of nanocarriers was quantified from the supernatant with spectrofluorometer

The sham surgery group (referred to as normal cartilage) was sacrificed at 12 weeks, and the only-defect groups with PBS injection (referred to as only-defect) were sacrificed at 4, 8, and 12 weeks when the injection groups were sacrificed

Liposomal or IV forms tend to have better absorption and are also considered safe when used appropriately

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In addition, experimental evidence confirmed that Nrf2 works against chemotherapy and radiotherapy (Wu et al