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Wu Y, Deng H, Sun J, Tang J, Li X, Xu Y
doi: 10.1210/en.2004-0733 Summary Keywords fibroblasts, melanocortin, drug development, resolution of inflammation, fibrosis Citation Khodeneva N, Sugimoto MA, Davan-Wetton CSA and Montero-Melendez T (2023) Melanocortin therapies to resolve fibroblast-mediated diseases
PL7737 has comparable potency to small molecule agonists (MK-0493, bivamelagon) that were inefficacious in general obese populations and RM-718 is less potent on MC3R and MC4R than setmelanotide, raising concerns for potential lack of efficacy in future general obesity trials
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Sevillano, J., Sanchez-Alonso, M
