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Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease

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4.4.2 Mechanistic hypotheses and clinical positioning Animal studies suggest that GLP-1RAs may restore ovulation by reducing local ovarian lipotoxicity and inflammatory/oxidative stress loads, thereby improving autophagy and PI3K/AKT/mTOR-related imbalances (131)