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Metformin restores PA-impaired GLP-1R level and PKA phosphorylation in HUVECs through AMP-activated protein kinase (AMPK) pathway It has been reported that metformin exerts its multiple metabolic actions via AMPK pathway 7

The biotransformation pathway comprises three phases: I oxidation, II conjugation, and III excretion

doi: 10.1016/j.neuropharm.2014.10.007 73 Aviles-OlmosIDicksonJKefalopoulouZDjamshidianAEllPSoderlundTet al

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