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In animal models of obesity and diabetes, increasing the protein to carbohydrate ratio in a high-fat diet results in a delay in the development of obesity while simultaneously improving glucose tolerance

Zonulin was shown to reversibly open tight-junctions in a protease-activated receptor 2 (PAR2) and epidermal growth factor receptor (EGFR) dependent manner resulting in dislocation of ZO-1 from the tight junction (71)

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