This is why clinicians adjust insulin and sulfonylureas carefully when starting GLP 1 therapy, and why nobody should stop basal insulin without a plan
Conclusions Changes in intra-portal insulin levels play an intricate yet permissive role in the regulation of the GH/IGF-I axis by either stimulating or suppressing hepatic GH sensitivity and hepatic IGF-I generation, probably via an insulin-mediated regulation of the hepatic GHR expression
It's like their metabolic protection system is running on empty
Interestingly, impaired vagal signaling may play a role in obesity, as decreased vagal activation to both mechanical stimuli and satiety-inducing signals is characteristic of a high-fat diet (HFD) 63,64,65,66
Others are incredibly fragile and may begin to degrade in a matter of days, regardless of the preservative
It can't handle 1 big one