Some studies indicate that GLP-1 RAs may help reduce the frequency of arrhythmias due to their beneficial impact on metabolic parameters and overall cardiovascular health (45) A recent systematic review and meta-regression analysis found that semaglutide significantly reduced the incidence of new-onset atrial fibrillation in patients with type 2 diabetes (46)
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Side Effects and Safety: What to Expect Most tirzepatide side effects are gastrointestinal, dose-dependent, and peak during titration
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Rigorous epidemiological studies would be required to determine whether any genuine association exists, and no such evidence currently supports a causal relationship between Wegovy and POTS development
Contraindications include personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2
