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Yes regular physical activity is strongly recommended

Bretaud, S., Allen, C., Ingham, P

Some research suggests that chronic high-dose L-carnitine supplementation may increase TMAO levels via gut bacteria metabolism, and elevated TMAO has been associated with increased cardiovascular risk in observational studies

ADP also relieves the inhibition of PFK-1 by ATP, but its concentration does not change as much with energy utilization

It is essential for the enzymes (deiodinases) that convert T4 into the active T3

But the relationship between thyroid function and weight loss on tirzepatide is more nuanced than that simple answer suggests