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Notable for: Multi-database design (improves generalizability) Active comparator framework Emphasis on short-term safety with acknowledgment of need for longer follow-up Diabetes Care Retrospective Cohort Evaluated thyroid tumors (broader outcome than confirmed malignancies) and found no increased risk with GLP-1 RA exposure in type 2 diabetes patients initiating second-line treatments

Lactoferrin can activate the IRS-1/PI3K/AKT pathway by facilitating insulin binding to IR

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