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Today, the two best-studied prescription options for weight management are semaglutide and tirzepatide, both of which are FDA-approved and widely used

Similar to GIP, the stimulatory effects of GLP-1 on insulin expression and secretion were observed in the presence of high (450 mg/dL) but not normal (99 mg/dL) concentrations of glucose in the cultured cells, indicating the glucose-dependent insulinotropic effect of GLP-1 (117)

What is fascinating is that their effects are not limited to alcohol: preclinical and correlational data indicate possible benefits in decreasing use of nicotine and opioids, which makes sense as alcohol, cannabis, opioid, and nicotine use disorders cluster together genetically into one brain disorder

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If that describes you, the front thigh is a reliable primary site, and your provider can help you assess which works best for your body composition

What exactly do these medications do