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Glutathione (GSH) is a tiny but mighty molecule made from three amino acids: glutamine, glycine, and cysteine

Van der Ploeg, A

In addition, as an NADPH-dependent coenzyme Q (CoQ) oxidoreductase, apoptosis-inducing factor mitochondria-associated 2 (AIFM2) can use NADPH to catalyse the regeneration of CoQ10 and act synergistically with GPX4 and GSH to inhibit phospholipid peroxidation and ferroptosis [77, 78]

Interestingly, these effects were more pronounced in the high-dose APLA group compared to PLA, suggesting dose- and type-dependent neurotoxicity (Qian et al., 2025)