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This mechanical stress not only precipitates a labral tear but also contributes to cartilage delamination and, ultimately, secondary osteoarthritis

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Cardiovascular Symptoms : Prolonged metabolic stress due to insufficient fatty acid oxidation can strain the heart, leading to cardiomyopathy or arrhythmias in some cases

This led to the first approved GLP-1 receptor agonist, exenatide (Byetta), in 2005 which binds to the same receptor but works far longer

Protein Kinase C activation mediates glucagon-like peptide-1induced pancreatic -cell proliferation

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