Visible improvement immediately after treatment , with a firmer and more refreshed appearance observed right after the session The patient commented that her face looked and felt more youthful and lifted immediately after leaving the treatment room Lifting and tightening effects continued to improve progressively over the following 3 to 7 days as collagen remodeling and tissue contraction developed beneath the skin After the full 600-shot treatment , the skin remained smooth and calm with minimal redness, swelling, or visible irritation Unlike some ultrasound-based lifting procedures, the patient described the treatment as significantly more comfortable , with little to no discomfort during the session No numbing cream or sedation was required , allowing the patient to return to daily activities immediately after treatment The advanced cooling system helped maintain comfort throughout the procedure while protecting the skin surface, contributing to a more pleasant overall treatment experience Note: Because XERF works by delivering thermal energy to stimulate collagen remodeling beneath the skin, mild warmth may remain within the treated tissue immediately after the procedure

Our discussion is based on interpreting the existing body of preclinical evidence for research design purposes
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Kendrick mass defect plots were used to validate the obtained identifications after manual inspection to filter out further false positive identifications