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These fatty acids are extremely susceptible to oxidative damage by free radicals or Reactive Oxygen Species (ROS) by a process called lipid peroxidation (LPO)

Erratum in: Nat Rev Gastroenterol Hepatol

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Restricting cysteine, depleting GSH, or inhibiting GPX4 can increase phospholipid peroxidation in responsive cells, but sensitivity also depends on lipid composition, iron metabolism, parallel antioxidant systems, and tissue context (Jiang et al., 2021)