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Under physiological conditions, ROS are generated in the heart mainly from the mitochondrial electron transport chain, nitric oxide synthases (NOS), NADPH oxidases (NOX), and xanthine oxidase (XO) in small quantities [7, 8]

In fact, GSH in the plasma is maintained at very low concentration because of the metabolism of GSH by many other cells (Sies and Graf, 1985

Trudler, D., Farfara, D

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