It's the copper
Figure 3 8.2 Relative stability and dynamic equilibrium of the tophi microenvironment Mature tophi function as relatively independent immune microenvironments, defined by distinctive physicochemical characteristics such as low pH and hypoxia
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The core materials for the study included GHK-Cu, and key fluorescent probes and antibodies were also critical components
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doi: 10.3390/nu13103319 100 VenturaM.MeloM.CarrilhoF