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Such changes could reduce the transamination activity, as suggested by an interference with the formation of diaminovalerate, a proposed metabolic intermediate in this catalytic reaction of GSAAT ( In light of experimental evidence showing the different monomeric and dimeric states of the Cys substitution mutants compared to GSAAT(WT), we propose that Cys168 and Cys190 are cruical for the protein activity and likely function as redox-active residues
Guessing the conversion introduces error larger than any calculation mistake
This mechanistic diversity enables applications across a broad spectrum of medical conditions and continues to expand as new targets and approaches are identified
Wirnitzer: This research work is part of both the Austria nationwide school study ( TWF Tiroler Wissenschaftsfrderung ID: UNI-0404/2413) as well as the college and university study ( TWF Tiroler Wissenschaftsfrderung ID: F.30976/6-2021), which are supported by the Austrian Federal Ministry of Education, Science, and Research (BMBWF), all Austrian Federal Education Authorities, as well as the Austrian Students' Union (H)
Malar J 24: 10144
