Figure 1 In patients with RA, tPO 2 in the joint cavity is significantly lower than that in normal tissues ( 3 Role of ROS and mitochondrial damage in RA inflammation Synovial inflammatory response is the central mechanism of RA lesions and main factor leading to pannus ( 3.1 Regulation of immune cell function 3.1.1 T cell In RA, immune cells function abnormally, producing a large number of inflammatory factors, such as tumor necrosis factor (TNF)-, interleukin (IL)-6, and IL-17, which are distributed in clusters in the diseased joints, causing an inflammatory storm (59)
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