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Treatment with exenatide increased the expression of SIRT1 in the ovaries, decreases androgen levels, and improves IR.78 Tao et al found that exenatide increased the expression of SIRT1 in the ovarian tissues of PCOS rats.79 Here, we found that semaglutide could also alleviate inflammation in PCOS mice by upregulating the AMPK/SIRT1/NF-B signaling pathway (Figure 6)

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Mathieu (Katholieke Universiteit Leuven, Leuven, Belgium) for serving as internal peer reviewers for the EASD and ADA

Read more #drugdevelopment #genericdrugs To view or add a comment, sign in "Both generic and brand-name drug manufacturers could promote measures to distinguish trustworthy GLP-1 products from substandard or unsafe alternatives," writes PRI's Sally Pipes