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Zheng J, Mitchell AE, Jones AD, Hammock BD

In CRC, ROS levels are frequently elevated due to enhanced mitochondrial activity, activation of oncogenic signaling pathways, and chronic inflammation [34]

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This was because hydroxocobalamin produced by bacteria was changed to cyanocobalamin during purification in activated charcoal columns after separation from the bacterial cultures (because cyanide is naturally present in activated charcoal)