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Intestinal OCT1 transport and metformin pharmacokinetics and efficacy As OCT1 is probably apically expressed it is most likely to influence local concentrations of metformin in the gut (lumen and enterocytes), rather than transfer into the blood

However, this is more of a supportive effect rather than a negative interference

There are compounds called reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals

The authors found that observations made previously in vivo could be reliably replicated in vitro with the organoid system, while being able to extract compelling new insights due to the tightly controlled nature of the organoid system (159)

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