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FXR in the dorsal vagal complex is sufficient and necessary for upper small intestinal microbiome-mediated changes of TCDCA to alter insulin action in rats

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Other GLP1 receptor agonists, such as Trulicity (dulaglutide), Wegovy (also semaglutide but at a higher dose for weight loss), and Victoza (liraglutide), offer similar mechanisms but vary in dosing frequency, cost, and clinical indications

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The NIHR 'Be Part of Research' service is the recommended starting point for patients seeking legitimate trial access