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Additionally, mtDNA damage has been associated with PD etiology and progression (Tresse et al., 2023) and mitochondrial dysfunction is linked genetically to PD, since many mutations associated to familial cases of PD were found in genes such as PINK1 or PARKIN, which regulate mitochondrial turnover (Valente et al., 2004
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As Hippocrates said, All disease starts in the gut. One of the lesser-known but nonetheless common root causes of hormone imbalances is dysbiosis, or an imbalance between good and bad bacteria, which is mostly housed in the gut
Several enzymes involved in ATP production contain Fe-S clusters in the active site and are subject to similar inactivation by superoxide, including oxoglutarate dehydrogenase of the tricarboxylic acid cycle, as well as ETC complexes IIII