doi: 10.1007/s10875-020-00920-5 58 ShahbazSXuLOsmanMSliglWShieldsJJoyceMet al
Often called the "master antioxidant," it is produced naturally by your body and exists in nearly every cell
It works by increasing levels of key brain chemicals like norepinephrine, dopamine, and serotonin, which can help suppress appetite, reduce emotional eating, and support sustained daily energy
Warning signs: Losing weight but looking "skinny fat" Strength declining in the gym Low energy and poor recovery Rapid scale loss (2+ lbs/week for multiple weeks) What to do: Protein target: 1.5-2g per kg of bodyweight (non-negotiable) Resistance train 3-4x per week (this signals your body to preserve muscle) Don't create extreme deficits 500-750 kcal below maintenance is plenty Consider creatine supplementation (3-5g daily) to support muscle retention Reason #5: Your Body Is Adapting (Metabolic Adaptation) If you've been on Reta for 8+ weeks with initial weight loss that has now stalled, your body may have adapted to the lower caloric intake
Adverse events We also conducted network meta-analyses to evaluate adverse events of GLP-1RA drugs, and the results implied safety concerns
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