Competition for Vitamin B 12 by intestinal parasites or bacteria
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Graphical Abstract Similar content being viewed by others Introduction Short-chain fatty acids (SCFAs) are metabolic end-products of gut microbial fermentation of indigestible dietary fibers in the human colon, with acetate, propionate, and butyrate constituting the major components at an approximate concentration ratio of 6.0:2.0:2.0 [1]
Gryffroy L, Ceulemans E, Manosalva Prez N, Venegas-Molina J, Jaramillo-Madrid AC, Rodrigues SD, De Milde L, Jonckheere V, Van Montagu M, De Coninck B, et al
New research to be presented at the European Congress on Obesity (ECO 2025) suggests that weight loss treatments using GLP-1 and dual GLP-1/GIP receptor agonists can lead to significant fat loss with minimal reduction in lean muscle mass
However, glucagon itself has recently been shown to be able to stimulate insulin secretion from the perfused mouse pancreas by a mechanism which appears to involve an interaction with GLP-1 receptors (since the effect was attenuated by exendin 9-39) (111), complicating assessment of the relative importance of any locally produced GLP-1
