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Phase 2 clinical trials involved 338 adults with obesity (BMI 30 or more) and overweight (BMI of 2729.99) with one or more weight-related conditions such as high blood pressure, high cholesterol levels, heart disease, and type 2 diabetes
Lotiglipron The development of lotiglipron for obesity and T2DM was prematurely stopped in early-phase clinical trials due to its association with elevated transaminases and potential liver toxicity
GLP-1 Agonists are a type of medicine used to treat type 2 diabetes, and some are also approved for treating obesity
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Importantly, glycemic control improved without increasing hypoglycemia risk, as the glucose-dependent nature of insulin secretion provides inherent safety
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