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Alterations in NO-mediated endothelium-dependent vasodilation results in widespread vasoconstriction and coagulation abnormalities and is considered to be an early step in the development of atherosclerosis

Current Medicinal Chemistry , 19 (1), 126132

Cost vs benefit: Given modest effect, the return may be limited compared to healthy habits (diet, sleep, sun protection)

Hence, include healthy fats in your meals, such as eggs, nuts, fatty fish, etc

Further complications such as necrosis, amputation, or renal failure may arise

It is a complex network of interlocking genetic feedback loops involving clock genes (Clock, Bmal1), period genes (Per1, Per2, Per3), and cryptochrome genes (Cry1, Cry2)