Key points GLP-1 is a hormone that increases insulin release and prevents the release of too much glucagon, helping manage blood glucose levels in individuals with type 2 diabetes GLP-1 receptor agonists, such as liraglutide and semaglutide, effectively reduce blood glucose levels Semaglutide is more effective than liraglutide at reducing blood sugar levels Tirzepatide is a newer GLP-1 receptor agonist that also mimics the actions of another hormone called GIP, which can also reduce blood sugar levels A randomised controlled trial showed that tirzepatide led to more significant blood sugar reductions than semaglutide across three doses Tirzepatide may be more effective than semaglutide at higher doses, but this needs further investigation Liraglutide and semaglutide are available in the UK and the US, while tirzepatide is only available in the US but is likely to be approved in the UK soon
That does not mean Trulicity is less effective overall
Given its effect on gastric emptying, patients may need to adjust meal sizes and frequency to manage any gastrointestinal side effects
Landmark roughly two to three finger-widths below the acromion process, into the densest part of the muscle, well clear of the shoulder bursa
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the study enforces the evidence that use of GLP-1 RA can reduce the weight gain attributable to insulin in this population