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To shed light on the interactions of the enzyme with the natural substrates, we docked flavan-3,3,4-triol ( 4 ) and flavan-3-on-4-ol ( 7 ) into the active pocket of the crystal structure of Pt GSTF8 obtained with ()-catechin ( 12 ) (Extended Data Fig

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As a result, Nrf2 escapes degradation and translocate to the nucleus, where it binds to Antioxidant Response Elements (AREs) within the promoter regions of target genes