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These effects have been recently associated with several molecular pathways [10,11,20,58,59,60,61,62,63,64,65,66], in particular with the increased expression and internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway [60,61], interacting particularly with the NO [49] and prostaglandins systems [50]

1 p Sustained was defined as having 2 consecutive measurements 28 days apart fulfilling the criteria

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The authors performed ChIP-Seq using expression constructs that yield AR DBD domains that are linked to functional domains that convey transcriptional activation or repression, both in benign and malignant prostate cells and organoids

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