Insulin, oxytocin, GLP-1, these aren't pharmaceutical inventions, they're native signals your biology already knows how to read
These medications work by: [1] stimulating insulin secretion slowing down gastric emptying (how quickly food leaves the stomach) reducing appetite and cravings slowing down the release of glucagon from the pancreas (a hormone that increases blood sugar when levels get too low)
Interestingly, relatively low concentrations of E2 are capable of robustly inhibiting germ cell apoptosis in cultured segments of human seminiferous tubules without survival factors (i.e., serum and hormones)
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Colombijn JMT, de Leijer JF, Visseren FLJ et al (2025) Effectiveness and safety of combining SGLT2 inhibitors and GLP-1 receptor agonists in individuals with type 2 diabetes: a systematic review and meta-analysis of cohort studies
Oral semaglutide is a different story entirely, with bioavailability around 1%