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La reduccin del IAH con tirzepatida es estadsticamente muy significativa pero no siempre suficiente para normalizar el ndice en todos los pacientes
The production of brain-derived neurotrophic factor (BDNF) in a CREB-dependent manner, which can prevent excitotoxic neuronal death by reducing the neurotoxic release of glutamate [60], has also been found to be increased following exenatide treatment in adult wild-type mice [97]
This is to avoid lipohypertrophy
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