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Mutations in two genes, PKD1 or PKD 2, lead to ADPKD

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The most commonly reported side effects are mild gastrointestinal symptoms such as nausea, bloating, and temporary changes in digestion particularly during dose escalation

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In pancreatic stellate cells under hypoxic conditions, melatonin induces apoptosis, modifies cyclin expressions, and initiates phosphorylation of MAPK, thereby reducing the viability of stellate and pancreatic cancer cells, and subsequently, impacting the tumor microenvironment and tumor progression [81]

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