Advise patients not to double their next dose [see DOSAGE AND ADMINISTRATION ]
performed a study in Croatia, an area characterized by moderate selenium deficiency, randomizing GH patients to therapy with methimazole (MMI) plus an antioxidant mixture containing -carotene, Vitamin C and Vitamin E and a relatively low dose of selenium (60 g), or MMI alone (55)
doi: 10.1016/j.trsl.2012.12.014
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reconstitute with sterile diluent for use
Both studies were conducted in accordance with Good Clinical Practice, the Declaration of Helsinki and US Food and Drug Administration/European Medicines Agency guidelines for studies in people with renal or hepatic impairment [12,13,14,15]