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With careful dose increases, close medical follow-up, and clear guidance on nutrition and hydration, most patients find that these symptoms ease as their body adjusts

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Future translational efforts should pursue several directions: first, conducting deep-phenotyping trials in biopsy-confirmed MASH patients, using positron emission tomography to quantify hepatic glucose uptake and correlating these findings with intrahepatic insulin signaling (e.g., p-AKT)

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This synergy arises from resveratrols ability to downregulate survivin and XIAP proteins, sensitizing cancer cells to 5-FU-induced DNA damage [61]