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While it might seem like a 1000 micrograms (mcg) B12 shot is equal to a 1,000 mcg B12 supplement, its not that simple

But interesting biology and plausible mechanisms are where drug development begins, not ends

MOTS-c: The cellular energy optimizer MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a mitochondrial-derived peptide produced from DNA inside the mitochondria that helps regulate energy and improve metabolic homeostasis at the cellular level

Delays in starting treatment

Anti-Aging, Peptides $149 Glutathione Glutathione is the master antioxidant

At this point, there is insufficient evidence to recommend B12 supplementation for fatigue beyond correcting a deficiency