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Additionally, DPP-4 inhibitors have been shown to improve abnormal liver transaminases levels such as aspartate aminotransferase and alanine transaminase, in patients with T2DM with liver dysfunction

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Several studies found that GLP-1RAs might have direct effects on adipogenesis, lipotoxicity, fatty acid oxidation, cytokines related to hepatitis and fibrosis, and intestinal microbiota (193, 195)

244 Additionally, somatostatin can inhibit gastrointestinal activity, reducing the secretion of pancreatic enzymes and gastric acid, thereby indirectly decreasing the demand for glucagon

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