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The equine neutrophilic proteinase inhibitors share their target specificity with eNAP-2, but in contrast they were stable at temperatures up to 100C and the inhibitory activity remained constant at a broad pH-range

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Nakamura, Y., Hirano, S., Suzuki, K

Sci Rep 11:6135

The water retention resolves within 710 days post-cessation as renal sodium handling normalizes