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While surveying the literature in preparation of this manuscript we have also noticed and reported an increasing interest in the role that GSTs play in neurodegeneration, where isozymes belonging to the family may be either up-regulated, mutated or absent, according to the different diseases

10.4049/jimmunol.0802814 J

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These are model-based observations

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When hormones stay out of balance for a prolonged period, you may experience problems such as extreme weight gain, poor digestion, difficulty sleeping, anxiety, depression, headaches, and heart disease