Zofran is a safe and effective treatment when used for FDA licensed indications
Meta-analyses and large trials report high rates of nausea, vomiting, diarrhea, and constipation in treated youths, typically mild to moderate in severity and diminishing over time (29, 37)
Previous studies on PanNETs, specifically insulinomas, have demonstrated a relationship between GLP- 1R expression and prognosis, indicating that the lack of GLP- 1R expression is associated with poor prognosis [25]
How to supplement when B12 tests are high Be sure you remove all sources of synthetic cyanocobalamin from your diet (supplements & fortified foods) Consider supplementing with iodine, selenium, and molybdenum which helps activate B2 (a B12 transport helper) Consider supplementing with an active B2 form (Riboflavin-5-Phosphate) - a B12 transport cofactor Consider taking intrinsic factor which helps the gut better absorb B12 Consider pulsing 4.5 mg of lithium orotate (2-3x per week) - helps the B12 transport Only supplement with bioidentical active B12 forms - hydroxocobalamin, methylcobalamin, adenosylcobalamin I know my specific COMT & VDR Taq gene details
doi: 10.1038/s41598-021-83008-3
Notably, the body stores some vitamin B12 in the liver, which can last for years