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One possibility is that changes in miR203-5p (and/or other miRNA molecules not examined in the present study) lead to transcriptional changes, potentially through other epigenetic mechanisms such as histone methylation/acetylation and heterochromatin modifications, that escalate over time and result in impaired glutamate homeostasis and glutamate-GABA communication

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The mechanisms behind the accelerated cognitive decline with this antioxidant combination are currently unclear